The Bruce Highway, approximately 45 kilometres north of Bowen is now open following an earlier traffic crash.
Initial information suggests that just before midnight last night, a hatchback collided with a four-wheel-drive heading in the opposite direction at Guthalungra.
The female driver of the hatchback has been airlifted to Townsville Base Hospital in a serious condition.
A female passenger of the hatchback and a male driver of the second vehicle both sustained injuries.
The Bruce Highway, at the scene of the crash, was closed for a period of time, but is now open.
There is no further information available at this stage. Investigations are continuing.
Anyone with information which could assist with this matter should contact Crime Stoppers anonymously via 1800 333 000 or crimestoppers.com.au 24hrs a day.
Crime Stoppers is a registered charity and community volunteer organisation working in partnership with the Queensland Police Service.
For all non-urgent police reporting or general police inquiries contact Policelink on 131 444 or Policelink.qld.gov.au 24hrs a day.