The Bruce Highway, approximately 45 kilometres north of Bowen is now open following an earlier traffic crash.
Initial information suggests that just before midnight last night, a hatchback collided with a four-wheel-drive heading in the opposite direction at Guthalungra.
The female driver of the hatchback has been airlifted to Townsville Base Hospital in a serious condition.
A female passenger of the hatchback and a male driver of the second vehicle both sustained injuries.
The Bruce Highway, at the scene of the crash, was closed for a period of time, but is now open.
There is no further information available at this stage. Investigations are continuing.
If you have information for police, contact Policelink on 131 444 or provide information using the online form 24hrs per day.
You can report information about crime anonymously to Crime Stoppers, a registered charity and community volunteer organisation, by calling 1800 333 000 or via crimestoppersqld.com.au 24hrs per day.