The Forensic Crash Unit is investigating a serious traffic crash on the Peak Downs Highway about 20 kilometres east of Nebo.
It is believed a car left the highway about 4am and rolled, resulting in serious injuries to two men, while another man has non-life threatening injuries.
The Peak Downs Highway will be closed in both directions for an indefinite period. Motorists are advised to avoid the area.
Diversions are in place via the Sarina-Marlborough Road and the Sarina-Oxenford Road.
Investigations are continuing.
There is no further information at this time.
Anyone with information which could assist with this matter should contact Crime Stoppers anonymously via 1800 333 000 or crimestoppers.com.au 24hrs a day.
Crime Stoppers is a registered charity and community volunteer organisation working in partnership with the Queensland Police Service.
For all non-urgent police reporting or general police inquiries contact Policelink on 131 444 or Policelink.qld.gov.au 24hrs a day.