Police are currently at the scene of a single vehicle truck on Boonah Beaudesert Road at Coulson.
Initial information suggests around 1.50pm the heavy vehicle has rolled approximately two kilometres east of the intersection with Gowan Road.
The male driver, and sole occupant, has sustained serious head injuries and will be transported by helicopter to the Princess Alexandra Hospital.
The Forensic Crash Unit is investigating.
The Boonah Beaudesert Road is currently closed in both directions. Motorists are asked to avoid the area.
Anyone with information which could assist police with their investigations should contact Crime Stoppers anonymously via 1800 333 000 or crimestoppers.com.au 24hrs a day.
Crime Stoppers is a charitable community volunteer organisation working in partnership with the Queensland Police Service.